Ketamine Therapy Blog — Mental Health Insights & Treatment Guides

Expert insights on ketamine therapy, depression, anxiety, PTSD, and mental health treatment — updated regularly by the Isha Health clinical team.

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Ketamine and Fear Memory Reconsolidation: A New Angle on

Ketamine and Fear Memory Reconsolidation: A New Angle on

NMDA receptors play a key role in fear memory reconsolidation. Here's how ketamine's mechanism may help disrupt traumatic memories and what this means for PTSD.

Ketamine for OCD: Emerging Evidence from a

Ketamine for OCD: Emerging Evidence from a

A 2013 proof-of-concept trial tested ketamine in obsessive-compulsive disorder. Here's what Rodriguez et al. found and what it may mean for treatment-resistant OCD patients.

Ketamine for Social Anxiety Disorder: Results from a

Ketamine for Social Anxiety Disorder: Results from a

A 2018 placebo-controlled crossover trial tested ketamine for social anxiety disorder. Here's what the results showed and what they mean for patients.

Ketamine for Generalized Anxiety Disorder: Dose-Related

Ketamine for Generalized Anxiety Disorder: Dose-Related

A 2017 dose-ranging study found that ketamine may reduce anxiety symptoms in patients with treatment-refractory anxiety disorders. Here's what the evidence shows.

Sublingual and Oral Ketamine for Depression: What

Sublingual and Oral Ketamine for Depression: What

Most ketamine research uses IV infusions, but many patients take ketamine orally or sublingually. Here's what the evidence shows about real-world outcomes with oral ketamine for depression.

Ketamine vs. Midazolam for Depression: A Two-Site

Ketamine vs. Midazolam for Depression: A Two-Site

The Murrough 2013 trial tested ketamine against midazolam in 73 patients with treatment-resistant depression. Here's what the results showed.

Ketamine for Suicidal Ideation: What a Meta-Analysis of

Ketamine for Suicidal Ideation: What a Meta-Analysis of

A 2018 meta-analysis in the American Journal of Psychiatry found that a single dose of ketamine may rapidly reduce suicidal ideation. Here's what clinicians and patients should know.

Ketamine and BDNF: How NMDA Blockade May Trigger

Ketamine and BDNF: How NMDA Blockade May Trigger

A 2011 Nature study showed that NMDA receptor blockade at rest triggers rapid BDNF release and antidepressant-like effects. Here's what that means for ketamine therapy.

Ketamine for PTSD: What the Clinical Evidence Shows

Ketamine for PTSD: What the Clinical Evidence Shows

A look at the Feder 2014 randomized trial on IV ketamine for chronic PTSD — what it found, why it matters, and what it means for patients seeking relief.

How Ketamine Works as an Antidepressant: The

How Ketamine Works as an Antidepressant: The

How does ketamine relieve depression so quickly? A look at the landmark 2006 Zarate trial and the NMDA receptor mechanism behind ketamine's rapid antidepressant effects.

Ketamine Troches

Ketamine Troches in Mental Health: Beginner's Guide

Ketamine Therapy

Ketamine troches are a dissolvable form of ketamine often used for depression, anxiety, and pain relief, offering a safe and convenient treatment option.

Does Ketamine Affect Male Fertility

Does Ketamine Affect Male Fertility?

Ketamine Therapy

Does Ketamine Affect Male Fertility? Explore research on its impact on sperm quality, reproductive health, and potential long-term fertility risks in men.

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