Ketamine Therapy Blog — Mental Health Insights & Treatment Guides
Expert insights on ketamine therapy, depression, anxiety, PTSD, and mental health treatment — updated regularly by the Isha Health clinical team.
6 Weeks of Oral Ketamine for TRD, PTSD, and OCD
A 2025 open-label study tested six weeks of oral ketamine for treatment-resistant depression, PTSD, and OCD. Improvements sustained across all three conditions.
Why Some Patients Respond Better to Ketamine
A pharmacogenetics pilot study explores why some patients respond better to esketamine. Genetic, clinical, and demographic variables all play a role.
Oral Ketamine for Depression: New RCT + Meta-Analysis
A 2025 randomized controlled trial and meta-analysis found oral ketamine effective for major depressive and bipolar disorder, with an NNT of 4.6.
Psychedelics for Borderline Personality Disorder?
A 2026 narrative review examines ketamine, esketamine, and psilocybin for BPD. Preliminary evidence suggests they may be safe and potentially beneficial.
Extended-Release Ketamine Tablets: Phase 2 Trial Results
A Nature Medicine Phase 2 RCT tested extended-release oral ketamine tablets for treatment-resistant depression. Results show efficacy with minimal side effects.
Ketamine for Chronic Pain: What 20 Years of RCTs Show
A 2026 systematic review analyzed two decades of randomized trials on subanesthetic ketamine for chronic non-cancer pain. Here's what the evidence says.
KAP Documentation: What Clinicians Must Know in 2026
DEA audits of ketamine clinics are increasing. What KAP-specific documentation do you need? Screening forms, session notes, and compliance templates.
Oral Ketamine for PTSD: 2026 Research Review
A 2026 review examines low-dose oral ketamine as a treatment for PTSD. How does at-home sublingual ketamine compare to IV infusions for trauma?
Ketamine for Teen Suicidal Ideation: First ED Trial
A pilot RCT tested IV ketamine for adolescent suicidal ideation in the emergency department. Here's what the Schlegelmilch 2026 study found.
Julian's Story: When Ketamine Worked
A senior attorney with treatment-resistant depression found rapid relief with ketamine — and learned why maintenance matters.
GLP-1 Agonists and Mental Health: Depression, Anxiety, Addiction
GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro) are being studied for effects on depression, anxiety, and addiction.
Ketamine Therapy & Insurance: How to Use a Superbill
Get reimbursed for ketamine therapy. Isha Health provides superbills for insurance claims — patients typically receive 20-50% back.
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