Ketamine Therapy Blog — Mental Health Insights & Treatment Guides

Expert insights on ketamine therapy, depression, anxiety, PTSD, and mental health treatment — updated regularly by the Isha Health clinical team.

Sublingual and Oral Ketamine for Depression: What Real-World Evidence Shows

Nov 3, 2025

Most ketamine research uses IV infusions, but many patients take it orally or sublingually. See what real-world evidence shows on oral ketamine for depression.

Ketamine vs. Midazolam for Depression: A Two-Site Randomized Controlled Trial

Oct 27, 2025

The Murrough 2013 trial tested ketamine against midazolam in 73 patients with treatment-resistant depression. Here's what the results showed.

Ketamine for Suicidal Ideation: What a Meta-Analysis of 298 Patients Found

Oct 20, 2025

A 2018 meta-analysis in the American Journal of Psychiatry found that a single dose of ketamine may rapidly reduce suicidal ideation.

Ketamine and BDNF: How NMDA Blockade May Trigger Neuroplasticity

Oct 13, 2025

A 2011 Nature study showed that NMDA receptor blockade at rest triggers rapid BDNF release and antidepressant-like effects.

Ketamine for PTSD: What the Clinical Evidence Shows

Oct 7, 2025

A look at the Feder 2014 randomized trial on IV ketamine for chronic PTSD — what it found, why it matters, and what it means for patients seeking relief.

How Ketamine Works as an Antidepressant: The NMDA-Glutamate Mechanism Explained

Oct 1, 2025

How does ketamine relieve depression so quickly? A look at the landmark 2006 Zarate trial and the NMDA receptor mechanism behind ketamine's rapid.

Ketamine Troches: Dosage, Effects, and How to Use

Aug 22, 2025Ketamine Therapy

Ketamine troches dissolve under the tongue for at-home depression treatment. Learn about dosage (100-200mg), effects, cost, and what to expect from lozenges.

Does Ketamine Affect Male Fertility?

Aug 15, 2025Ketamine Therapy

Does Ketamine Affect Male Fertility? Explore research on its impact on sperm quality, reproductive health, and potential long-term fertility risks in men.

Psychedelic Integration Therapy: A Complete Guide

Aug 8, 2025Ketamine Therapy

Explore Psychedelic Integration Therapy, its benefits, process, and how it helps integrate psychedelic experiences for healing and personal growth.

Ketamine vs Molly: Differences, Effects, Safety, and Risks

Aug 1, 2025Ketamine Therapy

Discover the differences between Ketamine vs Molly, their effects, risks, and safety considerations to understand how these substances compare.

The Matthew Perry Case - Prescribing Ketamine with Care and Context

Jul 29, 2025News

Prescribing ketamine with care and context ensures safe, effective treatment tailored to each patient’s needs, guided by clinical insight and compassion.

Does Ketamine Therapy Get You High

Jul 21, 2025Ketamine Therapy

Wondering if ketamine therapy gets you high? Learn how medical doses affect the mind, what sensations to expect, and how it's used safely for mental health.

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