Ketamine Therapy Blog — Mental Health Insights & Treatment Guides

Expert insights on ketamine therapy, depression, anxiety, PTSD, and mental health treatment — updated regularly by the Isha Health clinical team.

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Ketamine for OCD: Emerging Evidence from a Proof-of-Concept Crossover Trial

Ketamine for OCD: Emerging Evidence from a Proof-of-Concept Crossover Trial

A 2013 proof-of-concept trial tested ketamine in obsessive-compulsive disorder. Here's what Rodriguez et al.

Person reviewing therapy notes on a tablet

Why Your Therapy Notes Matter More Than You Think

Mental Health Technology

Therapy insights fade fast. See how AI documentation closes the gap between what happens in session and what you remember — and why it matters for KAP.

Ketamine for Social Anxiety Disorder: Results from a Randomized Crossover Trial

Ketamine for Social Anxiety Disorder: Results from a Randomized Crossover Trial

A 2018 placebo-controlled crossover trial tested ketamine for social anxiety disorder. Here's what the results showed and what they mean for patients.

Ketamine for Generalized Anxiety Disorder: Dose-Related Effects in Treatment-Refractory Patients

Ketamine for Generalized Anxiety Disorder: Dose-Related Effects in Treatment-Refractory Patients

A 2017 dose-ranging study found that ketamine may reduce anxiety symptoms in patients with treatment-refractory anxiety disorders. Here's what the evidence shows.

Sublingual and Oral Ketamine for Depression: What Real-World Evidence Shows

Sublingual and Oral Ketamine for Depression: What Real-World Evidence Shows

Most ketamine research uses IV infusions, but many patients take it orally or sublingually. See what real-world evidence shows on oral ketamine for depression.

Ketamine vs. Midazolam for Depression: A Two-Site Randomized Controlled Trial

Ketamine vs. Midazolam for Depression: A Two-Site Randomized Controlled Trial

The Murrough 2013 trial tested ketamine against midazolam in 73 patients with treatment-resistant depression. Here's what the results showed.

Ketamine for Suicidal Ideation: What a Meta-Analysis of 298 Patients Found

Ketamine for Suicidal Ideation: What a Meta-Analysis of 298 Patients Found

A 2018 meta-analysis in the American Journal of Psychiatry found that a single dose of ketamine may rapidly reduce suicidal ideation.

Ketamine and BDNF: How NMDA Blockade May Trigger Neuroplasticity

Ketamine and BDNF: How NMDA Blockade May Trigger Neuroplasticity

A 2011 Nature study showed that NMDA receptor blockade at rest triggers rapid BDNF release and antidepressant-like effects.

Ketamine for PTSD: What the Clinical Evidence Shows

Ketamine for PTSD: What the Clinical Evidence Shows

A look at the Feder 2014 randomized trial on IV ketamine for chronic PTSD — what it found, why it matters, and what it means for patients seeking relief.

How Ketamine Works as an Antidepressant: The NMDA-Glutamate Mechanism Explained

How Ketamine Works as an Antidepressant: The NMDA-Glutamate Mechanism Explained

How does ketamine relieve depression so quickly? A look at the landmark 2006 Zarate trial and the NMDA receptor mechanism behind ketamine's rapid.

Ketamine Troches

Ketamine Troches: Dosage, Effects, and How to Use

Ketamine Therapy

Ketamine troches dissolve under the tongue for at-home depression treatment. Learn about dosage (100-200mg), effects, cost, and what to expect from lozenges.

Does Ketamine Affect Male Fertility

Does Ketamine Affect Male Fertility?

Ketamine Therapy

Does Ketamine Affect Male Fertility? Explore research on its impact on sperm quality, reproductive health, and potential long-term fertility risks in men.

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