Ketamine Therapy Blog — Mental Health Insights & Treatment Guides

Expert insights on ketamine therapy, depression, anxiety, PTSD, and mental health treatment — updated regularly by the Isha Health clinical team.

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Neuroplasticity window after ketamine therapy practical guide

The Neuroplasticity Window: What to Do After Ketamine

Ketamine Therapy Basics

Ketamine triggers a 24-72 hour neuroplasticity window through BDNF release. Here is a practical guide to maximizing this window for lasting mental health.

CRPS chronic pain and ketamine treatment

Ketamine for CRPS: A Case of Long-Term Pain Relief

Research

A 2026 BMJ case report documents long-term relief of CRPS-associated limb dystonia with ketamine infusion. What this means for chronic pain patients.

Ketamine therapy for alcohol use disorder research

The Montreal Model: Ketamine Therapy for Alcohol + Depression

Research

A 2026 feasibility trial protocol combines structured ketamine therapy with psychotherapy for alcohol use disorder and treatment-resistant depression.

Group psychotherapy and ketamine treatment

Group Ketamine Therapy for Identity-Based Trauma

Research

A 2026 pilot study tested group ketamine-assisted psychotherapy for transgender adults experiencing identity-based trauma. Results showed significant improvements.

White House executive order on psychedelic mental health treatment April 2026

White House Accelerates Psychedelic Therapy for Serious Mental Illness: April 2026 Executive Order Explained

Isha Team

A physician's read on the April 2026 White House executive order accelerating psychedelic therapy for serious mental illness — what changes, what doesn't, and.

Trauma-informed care during ketamine therapy sessions

Trauma-Informed Care During Ketamine Treatment

For Clinicians

Patients referred for ketamine therapy often have complex trauma histories. A 2026 clinical protocol outlines trauma-informed nursing practices for safe.

Gut-brain axis and ketamine therapy

Ketamine and Your Gut: The Microbiome Connection

Research

New research reveals a bidirectional relationship between ketamine and the gut microbiome. How gut bacteria may influence ketamine's antidepressant effects.

Geriatric depression and ketamine therapy research

Ketamine for Depression in Older Adults with MCI

Research

Can ketamine treat depression in older adults with mild cognitive impairment? A 2026 editorial in the American Journal of Geriatric Psychiatry examines the evidence.

Ketamine therapy for opioid addiction research

Ketamine + Mindfulness for Opioid Addiction: RCT Results

Research

A 2026 Nature Mental Health RCT found ketamine-assisted mindfulness therapy significantly reduced drug use and cravings in patients with opioid use disorder.

State of psychedelic medicine 2026

Psychedelic Medicine in 2026: Where We Stand

Industry

From ketamine clinics to psilocybin trials and MDMA setbacks — a physician's overview of where psychedelic medicine stands in 2026 and what's next.

Oral ketamine for multiple psychiatric conditions

6 Weeks of Oral Ketamine for TRD, PTSD, and OCD

Research

A 2025 open-label study tested six weeks of oral ketamine for treatment-resistant depression, PTSD, and OCD. Improvements sustained across all three conditions.

Pharmacogenetics and personalized ketamine therapy

Why Some Patients Respond Better to Ketamine

Research

A pharmacogenetics pilot study explores why some patients respond better to esketamine. Genetic, clinical, and demographic variables all play a role.

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