Ketamine Therapy Blog — Mental Health Insights & Treatment Guides
Expert insights on ketamine therapy, depression, anxiety, PTSD, and mental health treatment — updated regularly by the Isha Health clinical team.
Combining Psychotherapy with Ketamine: The Evidence
A 2025 MDPI review examines the effects of psychotherapy on single and repeated ketamine infusions. Here is what the evidence says about combining molecular.
Using Aroma to Optimize Your Ketamine Session: The Science of Set, Setting, and Smell
Scent has the most direct biological line to the brain regions ketamine acts on. A practical, evidence-grounded guide to using aroma to optimize set, setting.
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The Montreal Model: Longer-Lasting Depression Relief
McGill University's Montreal Model clinical trial showed a 30% depression score drop sustained for 8+ weeks when combining ketamine with psychotherapy.
Ketamine vs ECT: Head-to-Head Trial Results
A 2024 secondary analysis in JAMA Network Open compared ketamine to ECT for treatment-resistant depression.
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11,000 Patients: At-Home Ketamine Depression Data
Mathai et al. 2024 published real-world data from 11,441 at-home telehealth ketamine patients in the Journal of Affective Disorders.
Esketamine Prevents Postpartum Depression: Meta-Analysis
A 2025 BMC Pregnancy and Childbirth meta-analysis finds perioperative esketamine during C-section significantly reduces postpartum depression incidence.
KARMA-Dep 2: Serial Ketamine Infusions for Inpatient Depression
The KARMA-Dep 2 trial published in JAMA Psychiatry tested serial ketamine infusions as adjunctive therapy for inpatient depression.
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Ketamine-Enhanced Prolonged Exposure for PTSD
A 2024 RCT protocol explores ketamine-enhanced prolonged exposure therapy for veterans with PTSD. Here is how combining ketamine with PE may improve trauma.
The Neuroplasticity Window: What to Do After Ketamine
Ketamine triggers a 24-72 hour neuroplasticity window through BDNF release. Here is a practical guide to maximizing this window for lasting mental health.
Ketamine for CRPS: A Case of Long-Term Pain Relief
A 2026 BMJ case report documents long-term relief of CRPS-associated limb dystonia with ketamine infusion. What this means for chronic pain patients.
The Montreal Model: Ketamine Therapy for Alcohol + Depression
A 2026 feasibility trial protocol combines structured ketamine therapy with psychotherapy for alcohol use disorder and treatment-resistant depression.
Group Ketamine Therapy for Identity-Based Trauma
A 2026 pilot study tested group ketamine-assisted psychotherapy for transgender adults experiencing identity-based trauma. Results showed significant improvements.
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