Is Ketamine Legal? Understanding the Legal Status of Ketamine Therapy

Ketamine Therapy Basics

Is Ketamine Legal? Understanding the Legal Status of Ketamine Therapy

Written by

Isha Team

published:

April 24, 2022

updated:

January 17, 2025

Is Ketamine Legal? Understanding the Legal Status of Ketamine Therapy

Ketamine is a medication that has been used for decades in the United States for various medical purposes, including as an anesthetic during surgical procedures. In recent years, ketamine has gained attention for its role in managing mental health conditions such as depression, anxiety, PTSD, and chronic pain. This has led many to ask: Is ketamine legal in the US? Is ketamine therapy legal for depression? Is ketamine legal in Oregon? This article will explore the legal status of ketamine in different contexts and address common questions about its use.

Ketamine’s Legal Status in the United States

Ketamine is legal in the US when prescribed by licensed medical professionals. Since its invention in the 1960s, ketamine has been approved for various medical uses, including anesthesia. The FDA approved ketamine as an anesthetic in 1970, and since then, its applications have expanded significantly, including its off-label use for mental health treatment.

Legal Uses of Ketamine

  • Anesthesia: Ketamine is widely used as an anesthetic in both human and veterinary medicine.
  • Mental Health Treatment: Ketamine therapy has shown promise in treating depression, anxiety, PTSD, and chronic pain at much lower doses than those used for anesthesia.
  • FDA-Approved Esketamine: In 2019, the FDA approved Spravato, an intranasal form of esketamine (a derivative of ketamine), specifically for treatment-resistant depression. This approval underscores ketamine’s growing role in mental health care.

Is Ketamine Legal for Depression?

Yes, ketamine therapy for depression is legal in the US when prescribed by a licensed practitioner. While traditional ketamine is used off-label for mental health conditions, its efficacy in improving mood and reducing depressive episodes has been extensively studied. Off-label use means that the medication is prescribed for a purpose not specifically approved by the FDA but is considered safe and effective based on research and clinical experience.

Off-Label Ketamine Use

Off-label ketamine use is completely legal and widely practiced. Many FDA-approved drugs are used off-label for various conditions, and ketamine is no exception. It has been shown to:

  • Reduce symptoms of depression: Patients often experience rapid relief within hours.
  • Promote neuroplasticity: Low doses of ketamine can help form new neuronal connections, improving mood and cognitive function.

Is Ketamine Legal in Oregon?

Ketamine is legal in Oregon for medical purposes, just as it is in other states. Licensed medical practitioners in Oregon can prescribe ketamine for FDA-approved uses as well as for off-label indications such as depression, anxiety, and PTSD. Oregon is also at the forefront of exploring psychedelic-assisted therapies, which has increased public interest in treatments like ketamine therapy.

Is Ketamine Therapy Legal?

Ketamine therapy is legal throughout the US when provided by a licensed healthcare professional. Clinics offering ketamine therapy operate under strict medical guidelines to ensure patient safety and compliance with federal and state laws.

What Makes Ketamine Therapy Legal?

  • DEA Schedule III Status: Ketamine is classified as a Schedule III substance by the DEA, meaning it has a recognized medical use but requires careful regulation to prevent misuse.
  • Licensed Prescriptions: Only licensed medical professionals can prescribe ketamine therapy, ensuring that its use is both safe and legal.

When Is Ketamine Illegal?

Ketamine is illegal when used outside of a medical context. Recreational use of ketamine, often referred to by names like "Special K" or "Vitamin K," involves much higher doses than those prescribed for medical purposes. Street ketamine is often adulterated with other substances, increasing the risk of serious side effects or harm.

Risks of Illegal Ketamine Use

  • Unregulated Doses: Recreational ketamine is often consumed at dangerously high doses.
  • Adverse Effects: Side effects such as dissociation, nausea, and dizziness can become severe without medical supervision.
  • Legal Consequences: Possession or use of ketamine without a prescription is against the law and can result in significant legal penalties.

FDA and DEA Oversight

Ketamine is regulated by both the FDA and the DEA:

  • FDA: Approves medical uses of ketamine and its derivatives, such as esketamine (Spravato), ensuring safety and efficacy.
  • DEA: Classifies ketamine as a Schedule III substance due to its potential for misuse while recognizing its medical value.

Isha Health’s Commitment to Safe and Legal Ketamine Therapy

At Isha Health, we prioritize your safety and well-being. Our board-certified practitioners offer ketamine-assisted therapy that is:

  • Scientifically Backed: Based on the latest research and clinical trials.
  • Fully Legal: Compliant with all federal and state regulations.
  • Convenient: Available from the comfort of your home, under the supervision of licensed professionals.

If you’re considering ketamine therapy, contact us at info@isha.health to learn more about this innovative treatment and whether it’s right for you.

Conclusion

Ketamine is legal for medical use in the US, including as a treatment for depression, anxiety, PTSD, and chronic pain. Whether you’re seeking traditional ketamine therapy or the FDA-approved esketamine nasal spray, it’s essential to work with licensed medical professionals to ensure safety and legality.

If you have questions like, "Is ketamine legal for depression?" or "Is ketamine legal in Oregon?", rest assured that under the care of qualified practitioners, ketamine therapy is a safe and legal option for improving mental health.

References:

  • American Psychiatric Association. (2017). Practice guideline for the treatment of patients with major depressive disorder. Retrieved from https://psychiatryonline.org/pb/assets/raw/sitewide/practice_guidelines/guidelines/mdd.pdf
  • Niciu, M. J., & Zarate Jr, C. A. (2015). Ketamine: A potential rapid-acting antidepressant. Expert Opinion on Investigational Drugs, 24(2), 169-181. doi: 10.1517/13543784.2015.989731
  • Newport, D. J., Carpenter, L. L., McDonald, W. M., Potash, J. B., Tohen, M., Nemeroff, C. B., & APA Council of Research Task Force on Novel Biomarkers and Treatments. (2015). Ketamine and other NMDA antagonists: Early clinical trials and possible mechanisms in depression. The American Journal of Psychiatry, 172(10), 950-966. doi: 10.1176/appi.ajp.2015.15040465
  • Rodriguez, C. I., Kegeles, L. S., Levinson, A., Feng, T., Marcus, S. M., Vermes, D., … & Lapidus, K. A. (2019). Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: Proof-of-concept. Neuropsychopharmacology, 44(6), 1222-1229. doi: 10.1038/s41386-019-0333-7
  • Sinner, B., & Graf, B. M. (2008). Ketamine. Handbook of Experimental Pharmacology, 182, 313-333. doi: 10.1007/978-3-540-74806-9_14
  • US Drug Enforcement Administration. (n.d.). Drug scheduling. Retrieved from https://www.dea.gov/drug-scheduling
  • US Food and Drug Administration. (2019). FDA approves new nasal spray medication for treatment-resistant depression; available only at a certified doctor’s office or clinic. Retrieved from https://www.fda.gov/news-events/press-announcements/fda-approves-new-nasal-spray-medication-treatment-resistant-depression-available-only-certified-doctors

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