Post-traumatic stress disorder (PTSD) affects approximately 6% of the U.S. population at some point in their lives, causing intrusive memories, hyperarousal, and emotional numbness that can severely disrupt daily functioning. While first-line treatments such as SSRIs and trauma-focused psychotherapy help many people, a significant number of patients do not respond adequately. Emerging evidence suggests that ketamine may offer a novel approach for individuals with PTSD, particularly those who have not found relief through conventional treatments.
A randomized controlled trial by Feder et al. (2014), published in JAMA Psychiatry, found that a single intravenous ketamine infusion produced a rapid and significant reduction in PTSD symptom severity compared to an active placebo (midazolam) in patients with chronic PTSD. A follow-up study by the same group (Feder et al., 2021) examined repeated ketamine infusions and reported that two weeks of ketamine treatment led to greater improvement in PTSD symptoms compared to midazolam, with effects observed as early as 24 hours after the first infusion.
While these results are encouraging, it is important to note that research on ketamine for PTSD is still evolving. Most studies have been relatively small, and long-term outcomes require further investigation. Ketamine is not FDA-approved for PTSD and is used off-label when prescribed for this condition. For a deeper review of the clinical evidence, see our article on ketamine and PTSD clinical evidence.
1. Consultation
Schedule a 60-minute telehealth evaluation with a physician who specializes in ketamine-assisted therapy. We assess your PTSD symptoms, treatment history, and overall suitability.
2. Personalized protocol
If ketamine therapy is appropriate for you, your physician creates a tailored treatment plan. Medication is prescribed and delivered to your home.
3. Ongoing support
Complete at-home sessions with continued clinical follow-up. Your physician monitors your response and adjusts your protocol as needed.
Preliminary research suggests that ketamine may help reduce PTSD symptoms, particularly intrusive thoughts and hyperarousal. Several clinical studies have shown rapid improvement in PTSD symptom scores following ketamine administration, though more large-scale research is needed.
Some studies have reported improvement in PTSD symptoms within 24 hours of ketamine administration. However, individual responses vary, and a full course of treatment is typically recommended for sustained benefit.
Ketamine is not FDA-approved specifically for PTSD. It is FDA-approved as an anesthetic and is prescribed off-label by licensed physicians for PTSD and other mental health conditions based on emerging clinical evidence.
Treatment begins with a 60-minute telehealth consultation with a physician who evaluates your symptoms and history. If appropriate, a personalized ketamine protocol is prescribed and medication is delivered to your home. Ongoing follow-up appointments monitor your progress.
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